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Basic Pharmacokinetics Concepts for the Pharmaceutical Scientist
Application-based
Live Short Course | 25 contact hours
July 13-July 16, 2010
More information coming soon!
Who should register
If you are an academic or industrial scientist seeking a basic understanding of pharmacokinetics and pharmacodynamics to further your work, then this intensive short course will be advantageous for your career. You will also benefit from this course if you wish to enhance your interactions with scientists in pharmacokinetic and drug delivery research. Additionally, the concepts you will develop are essential in the evaluation of traditional dosage forms and innovative medical delivery systems and devices.
At the conclusion of this course, participants will be able to:
relate the concepts of clearance and volume of distribution to physiological processes that influence the absorption, distribution, metabolism and excretion of drugs and chemicals.
calculate essential pharmacokinetic parameters, such as the rate and extent of absorption, clearance, volume of distribution and half-life from simple concentration-time data sets.
apply fundamental pharmacokinetic principles to the evaluation of ADMET studies that are encountered in the pre-clinical and clinical phases of drug development.
8:15-9:00 a.m.
Pharmacokinetics in Drug Discovery and Development
Absorption, Distribution, Metabolism, and Excretion in Drug Discovery and Development
9:00-10:00 a.m.
Clearance Concepts I
General concept, renal and hepatic
8:15-9:30 a.m.
Constant Rate Input and Multiple Dose Regimens
Steady state concept, one-compartment model, linear systems, superposition, approach to steady state
BREAK (9:30-9:45 a.m.)
Workshop 5 (9:45-10:45 a.m.)
Intravenous Infusion and Multiple Dosing Data analysis and applications
10:45 a.m. - 12:00 p.m.
Nonlinearity in ADME
Nonlinear absorption, elimination with respect to concentration or time
LUNCH (12:00-1:30 p.m.)
Afternoon:
1:15-2:45 p.m.
Integration of Kinetic Concepts and Physiological Parameters
Integration of ?ow, binding, enzyme activity
BREAK (2:45-3:00 p.m.)
3:00-4:00 p.m.
Pharmacokinetic Basis of Drug Interactions
In?uence of co-medication on physiologic and pharmacokinetic parameters
Workshop 6 (4:00-5:00 p.m.)
Drug Interactions
Prediction of drug interactions based on clearance and volume concepts
Workshop 7 (10:00-11:00 a.m.)
Pharmacodynamic Modeling Applications and data analysis
11:00 a.m. - 12:00 p.m.
Pharmacogenomics: Genetic Basis for Variability in Pharmacokinetics
Polymorphisms in drug transporters and metabolizing enzyme and effects on ADME
LUNCH (12:00-1:00 p.m.)
Afternoon:
1:00-2:15 p.m.
Kinetics of Drug Targeting
Concept of targeted bioavailability, kinetic analysis of targeted administration
BREAK (2:15-2:30 p.m.)
2:30-3:30 p.m.
Animal-Human Correlations
Animal scale-up, allometry, physiologically-based pharmacokinetic models, ?rst dose in man considerations
3:30-4:30 p.m.
Examples of Non-Compartmental and Compartmental Data Analysis
Analysis of real-life data to determine and interpret pharmacokinetic parameters
Ronald J. Sawchuk, Ph.D.
Professor of Pharmaceutics
Director of Bioanalytical and Pharmacokinetic Services Laboratory
College of Pharmacy, University of Minnesota
Cheryl L. Zimmerman, Ph.D.
Professor
and Director of Graduate Studies in Pharmaceutics
College of Pharmacy, University of Minnesota
In order to qualify for a group discount, all registrations must be submitted together*. Group discounts for the course are available, according to the following schedule:
4-day course
# of Participants
Discount
Cost/Participant
2
$100
$2,700
3-4
$200
$2,600
5+
$300
$2,500
3-day course
# of Participants
Discount
Cost/Participant
2
$100
$2,000
3-4
$200
$1,900
5+
$300
$1,800
*Please call 612-625-8616 (or toll free at 1-800-633-6638) before registering online to receive your discount.
A Welcome Reception will be held on Monday, July 12 from 5:30 - 7:30 PM at the McNamara Alumni Center. Here you will have the opportunity to meet the course instructors, and mingle with fellow colleagues.
On Thursday, July 15 from 6:00pm-8:00pm enjoy a relaxing dinner to celebrate your new found knowledge at the exclusive Campus Club, located on the 4 floor of Coffman Memorial Union.
A block of rooms has been set up at the Radisson Hotel - Metrodome. The room rate is $113/night. Upon registration, reservation information will be emailed to you.
If you are planning to rent a car we can cover the cost of your parking on campus during the day for the course, but we are unable to pay for parking charges assessed by the hotel.
Registration deadline is June 28, 2010. Registrations received after June 28 will be subject to a $100 late registration fee. Cancellations made before June 28, 2010 will be charged a $200 administrative fee. Cancellations after June 28, 2010 are non-refundable.
Those registering with a group call 612-625-8616 (or toll free at 1-800-633-6638) before registering online to receive your discount.
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Basic Pharmacokinetics Concepts for the Pharmaceutical Scientist
